The phosphorylated HER3 provides docking sites for p85 subunit of PI3K. The totally activated PI3K sophisticated is produced by binding of p110 subunit of PI3K to p85 which can develop PIP3 by using phosphorylating the PIP2. AKT binds to PIP3 and it is phosphorylated by PDK1 and mTORC2. Phosphorylat